Comparison to Classic column based synthesizers

Kilobaser: the smart cartridge based DNA synthesizer

Kilobasers is designed as a personal DNA synthesizer to fulfill the needs of individual scientists or small labs. Due to its low price point, its reagents cartridge technology & full automation which makes it extremely simple to operate, it’s fixed yield of 300pMol and the single column microfluidic chips its the perfect choice for scientists to accelerate their research.


Kilobaser Classic column based synthesizers
Acquisition costs
Reagent consumption / waste
Automation / hands-on time
Oligo modification flexibility
Parallel columns
User friendliness


  • kilobaser
    • 15.000 € / 18.000 USD
      • Local touchscreen and remote control
      • 5mL for 100 bases DNA
      • Basic ventilation
      • automatic final deprotection
      • Oligo modification flexibility:
        limited modifications
      • Parallel columns:
        single column
      • reagent cartridge
      • 300 pMol
    • request sample oligo
  • Classic column based synthesizers
    • > 35 000 € / 40 000 USD
      • External computer needed
      • 50 - 100 x more
      • Fume hood / exhaust needed
      • manual final deprotection
      • Oligo modification flexibility:
        any modification
      • Parallel columns:
        2 - ? columns
      • > 10 reagent bottles
      • >10 nMol

In contrast the classic DNA synthesizer available on the market are rather production machines, suffering from a high price point, complex operation and high reagent consumption, but offering more flexibility and maximum output in terms of yield, parallel columns, high customizability. These classic DNA synthesizers are usually operated by synthesis service providers or seperate synthesis departments in larger organisations.

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