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modified RNA

fully 2′ MOE modified backbone

The 2′-O-methoxyethyl RNA backbone (2′-MOE) offers improved duplex stability, significant nuclease resistance, and relatively low toxicity. As a result, 2′-MOE is an attractive backbone for many therapeutic approaches.

Synthesize your custom modified RNA oligos with Kilobaser Personal Synthesizer right in the lab, whenever you need them. They are ready!

Choose your RNA modifications combination

to customize your RNA oligos even more

RNA Modifications available:

Full 2' MOE modified

Full 2' MOE & fully phosphorothioated backbone

with Optional:

5' Phosphorylation

5' 6-FAM Labeling

5' Aminomodification

Soon Available:

Full/selective 2' Fluoro modified

Full/selective 2' OMe

3' GalNac conjugation

Selective phosphorothioate backbone

RNA Synthesis with Kilobaser

Ready-to-use RNA in 3 steps

enter sequence

Enter your RNA sequence using the included touch screen, USB flash drive or your computer.

insert chip & cartridge

Insert Kilobasers' patented microfluidic chip & reagent cartridge for your custom RNA oligo synthesis.

Press start

Within two hours you get your ready-to-use custom modified RNA oligo!

You want to learn more about synthesis with Kilobaser personal synthesizer?

About the new approach

Traditional medicine, based on antibodies and small molecules, directly targets the disease-causing protein as soon as it is produced (translated). Consequently, the protein function is blocked.
However, this approach fails to treat diseases caused by reduced protein production and must be dosed carefully.

Modified RNA like siRNA regulates mRNA translation. Kilobaser personal RNA synthesizer.

Of particular interest for drug development is cell process regulating RNA, such as small interfering RNA (siRNA). Complementary binding to protein-coding mRNA blocks the translation of specific proteins.
In case of siRNA malfunction, this cellular regulation is mimicked in RNA-based therapeutics by antisense oligonucleotides.

RNA-based therapeutics are changing the way diseases are treated and even enabling the treatment of previously untreatable diseases.
Advance research with us and synthesize modified RNA in your lab with Kilobaser modified RNA cartridge.

FAQ – modified custom RNA oligos

For which applications can I use the RNA produced with Kilobaser Synthesizer?

These RNA products are suitable for research and development only and should not be used for therapeutic purposes.

Are the RNA oligos ready to use?

Yes! With the Kilobaser you will get crude dryed custom RNA oligos. Since the synthesis requires extremely few reagents, the by-products in your synthesis are minimal. No need for extra purification.

Can I also synthesize RNA FISH probes?

YES, you can!

With Kilobaser you are able to synthesize fully 2' MOE modified RNA or fully phosphorothioated RNA labeled on 5'-end with 6-FAM fluorescent dye.

How can I order the 5' modifications?

For RNA with 5'- modification, write a mail to [email protected]

You have further questions? Visit our FAQ-section.

or send us a message:

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We are happy to help you

Lisa-Marie Michelitsch​

Master of Science
Biotechnology

[email protected]
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