DNA Nucleotides Adenin, Guanin, Thymin, Cytosin. Kilobaser DNA Graphic. Kilobaser benchtop DNA Synthesizer.
RNA Nucleotides Adenin, Guanin, Uracil, Cytosin. Kilobaser RNA Graphic. Kilobaser benchtop RNA Synthesizer.

Modified RNA

next generation of drug development

Ribonucleic acid (RNA) is found in all living cells. As a transcription of DNA, RNA is the link to a functional proteom. Depending on its function, RNA occurs in different forms. Since diseases are often caused by a missing or dysfunctional protein, RNA-based therapeutics become more and more popular in the treatment of various diseases.

DNA Nucleotides Adenin, Guanin, Thymin, Cytosin. Kilobaser DNA Graphic. Kilobaser benchtop DNA Synthesizer.
RNA Nucleotides Adenin, Guanin, Uracil, Cytosin. Kilobaser RNA Graphic. Kilobaser benchtop RNA Synthesizer.

the new approach

Traditional medicine, based on antibodies and small molecules, directly targets the disease-causing protein as soon as it is produced (translated). Consequently, the protein function is blocked.
However, this approach fails to treat diseases caused by reduced protein production and must be dosed carefully.

Of particular interest for drug development is cell process regulating RNA, such as small interfering RNA (siRNA). Complementary binding to protein-coding mRNA blocks the translation of specific proteins.
In case of siRNA malfunction, this cellular regulation is mimicked in RNA-based therapeutics by antisense oligonucleotides.

RNA-based therapeutics are changing the way diseases are treated and even enabling the treatment of previously untreatable diseases.

Advance research with us and synthesize modified RNA in your lab with Kilobaser modified RNA cartridge.

Kilobaser DNA and RNA benchtop Synthesizer for in-house RNA and DNA Synthesis. Microfluidic chip based. Synthesize RNA oligos, DNA oligos, DNA primer, DNA probes in less than 2h. 2'MOE RNA cartridge fo benchtop DNA Synthesizer.
Kilobaser DNA and RNA benchtop Synthesizer for in-house RNA and DNA Synthesis. Microfluidic chip based. Synthesize RNA oligos, DNA oligos, DNA primer, DNA probes in less than 2h. 2'MOE RNA cartridge fo benchtop DNA Synthesizer.

Independent drug development with Kilobaser In-house RNA Synthesis

RNA Modifications available:

Full 2' MOE modified

Full 2' MOE & fully phosphorothioated backbone

Optional:

5' Phosphorylation

5' 6-FAM Labeling

5' Aminomodification

Soon Available:

Full/selective 2' Fluoro modified

Full/selective 2' OMe

3' GalNac conjugation

Selective phosphorothioate backbone

Want to test our new product?

Kilobaser empowers you to develop RNA-based therapeutics faster and more efficiently.

Modified RNA reagent cartridge for Kilobaser desktop RNA Synthesizer. In-house RNA/DNA Synthesis for fast and independent drug development.

You have further questions? Maybe you will find the answer in our FAQ-section.

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We are happy to help you

Lisa-Marie Michelitsch​

Master of Science
Biotechnology

sales@kilobaser.com
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