Introducing the New Hexynyl Cartridge: Revolutionary Click Chemistry at Your Fingertips
Today, we're excited to announce the newest addition to our reagent cartridge family – the Hexynyl Cartridge for Kilobaser DNA & RNA Synthesizers. This innovative cartridge brings the power of click chemistry directly to your lab bench, expanding the possibilities for custom oligonucleotide modifications and applications.
What is Hexynyl Modification?
The Hexynyl modification introduces a terminal alkyne group to your oligonucleotides, creating a powerful platform for further modifications through click chemistry. This allows you to attach azide-labeled molecules to your DNA or RNA sequences, opening doors to a wide range of applications in research, diagnostics, and therapeutics.
With the Hexynyl Cartridge, you can modify your now hexynyl-anchored oligos with any Azide-functionalized molecule available:
Attach fluorescent dyes, quenchers, or other functional groups post-synthesis
Create custom-labeled probes for advanced imaging applications
Develop bioconjugates with improved cell penetration capabilities
Design complex molecular tools with precise spatial organization
About Click Chemistry
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The principle of CuAAC
In click chemistry, two functional groups bind to each other, each on a molecule. We use Cu(I)-catalyzed azide-alkyne click chemistry (CuAAC). As the name implies, the binding reaction is catalyzed by Cu(I) ions. Thus, the DNA-bound 5’-Hexynyl Phosphoramidite anchor binds in a Cu(I) environment with the azide conjugated dye to form a stable alkyne.
Seamless Integration with Your Kilobaser System
Like all our cartridges, the new Hexynyl Cartridge integrates perfectly with our microfluidic chip technology, maintaining the simplicity and efficiency you've come to expect from Kilobaser. The unique cartridge and chip system ensures:
Fast synthesis – ready-to-use oligos in under 2 hours
Easy handling – no contact with hazardous chemicals
Minimal waste – environmentally friendly synthesis without halogenated solvents
Expanding Your Research Horizons
The Hexynyl Cartridge is compatible with our Kilobaser one-XT systems, allowing for flexible integration into your existing workflows. Whether you're developing new diagnostic tools, exploring novel therapeutic approaches, or pushing the boundaries of synthetic biology, the Hexynyl Cartridge provides the foundation for innovative research.
"The addition of the Hexynyl Cartridge to our product lineup represents our commitment to expanding the capabilities of benchtop DNA and RNA synthesis," says CEO Alexander Murer. "We're giving researchers more tools to create exactly what they need, when they need it, without waiting weeks for outsourced synthesis."
Getting Started
The Hexynyl Cartridge and Hexynyl Label Chip are now available through our webshop and authorized distributors.
Ready to explore the possibilities? Book a live online demo to see how easy it is to use the Hexynyl Cartridge with your Kilobaser system. Our team will walk you through the workflow and answer any questions you might have about integrating this powerful modification into your research.
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